Evaluation of Genotoxic and Cytotoxic Activity of Ganoderma Lucidum In Rat Bone Marrow Induced By Lipopolysaccharide
نویسندگان
چکیده
Objective: It was aimed to investigate the antigenotoxic effect of Ganoderma lucidum against damage caused by lipopolysaccharide (LPS) in rat bone marrow cells micronucleus test and comet analysis.
 Method: In experiment, 28 Wistar albino female rats were used 4 groups formed. Only physiological saline applied control group. A single dose 7.5 mg/kg LPS administered intraperitoneally LPS+ (GL): given gavage at a 50 per day for one week. Then, on 8th day, intraperitoneally. group: GL 1 After 24 hours, euthanized cervical dislocation under anesthesia. Analyzes performed percentage micronucleated polychromatic erythrocytes (MNPCE) Polychromatic erythrocytes/Normochromatic (PCE/NCE) ratio DNA femur cells.
 Results: When PCE/NCE examined, no statistical significance observed when compared both with among themselves. Compared group, it that parameters experimental (excluding head DNA) increased significantly. Length tail (L tail), DNA, olive moment (OTM) values significantly different While there significant difference between LPS+GL group Tail Moment (TM) value comet) value, groups.
 Conclusion: all findings is considered, cannot be classified as genotoxic agent. We can say, however, reverses issue.
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ژورنال
عنوان ژورنال: Dicle Medical Journal
سال: 2022
ISSN: ['1300-2945', '1308-9889']
DOI: https://doi.org/10.5798/dicletip.1086124